Assay Detail
Functional
CHEMBL833122
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Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.63 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58711 | TIVIRAPINE | 2.0 | 1 | 8.34 |
| CHEMBL293498 | — | — | 1 | 7.48 |
| CHEMBL70329 | — | — | 1 | 7.00 |
| CHEMBL72418 | — | — | 1 | 6.80 |
| CHEMBL72857 | — | — | 1 | 6.40 |
| CHEMBL373023 | — | — | 1 | 6.21 |
| CHEMBL348795 | — | — | 1 | 4.21 |
| CHEMBL193974 | — | — | 1 | - |
| CHEMBL419819 | — | — | 1 | - |
| CHEMBL72825 | — | — | 1 | - |
| CHEMBL70253 | — | — | 1 | - |
| CHEMBL70654 | — | — | 1 | - |
| CHEMBL72759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58711 | TIVIRAPINE | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL293498 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL70329 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL72418 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL72857 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL373023 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL348795 | — | EC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL193974 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL419819 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL72825 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL70253 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL70654 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL72759 | — | EC50 | > | 50000.0 | nM | - |