Assay Detail
Functional
CHEMBL833126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to achieve 50% protection of infected MT-4 cells from Y181C-HIV-1 strain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Docking and 3-D QSAR studies on indolyl aryl sulfones. Binding mode exploration at the HIV-1 reverse transcriptase non-nucleoside binding site and design of highly active N-(2-hydroxyethyl)carboxamide and N-(2-hydroxyethyl)carbohydrazide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366702 | — | — | 1 | 8.00 |
| CHEMBL283950 | L-737126 | — | 1 | 7.70 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.60 |
| CHEMBL176239 | — | — | 1 | 7.52 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366702 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL283950 | L-737126 | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL176239 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 30000.0 | nM | - |