Assay Detail
Functional
CHEMBL833212
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Cytotoxic activity against human tumor Aro cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ARO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.69 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191451 | — | — | 1 | 5.40 |
| CHEMBL191904 | — | — | 1 | 5.30 |
| CHEMBL192687 | — | — | 1 | 5.10 |
| CHEMBL192764 | — | — | 1 | 4.16 |
| CHEMBL192703 | — | — | 1 | 4.10 |
| CHEMBL364959 | — | — | 1 | 4.10 |
| CHEMBL192696 | — | — | 1 | - |
| CHEMBL373331 | — | — | 1 | - |
| CHEMBL192846 | — | — | 1 | - |
| CHEMBL557572 | — | — | 1 | - |
| CHEMBL501867 | VINCRISTINE SULFATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191451 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL191904 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL192687 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL192764 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL192703 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL364959 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL192696 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL373331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192846 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL557572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL501867 | VINCRISTINE SULFATE | IC50 | < | 0.1 | nM | - |