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Assay Detail

CHEMBL833218

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration of compound against growth of HCT116 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Intermediate

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.
Kuo GH, Deangelis A, Emanuel S, Wang A, Zhang Y, Connolly PJ, Chen X, Gruninger RH, Rugg C, Fuentes-Pesquera A, Middleton SA, Jolliffe L, Murray WV.
J Med Chem (2005) 48 : 4535 -4546
PubMed 15999992 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.64 7.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL191336 1 7.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL191336 IC50 = 23.0 nM 7.64