Assay Detail
Functional
CHEMBL833229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against cell proliferation in human A375 (malignant melanoma),tumor cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.98 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261720 | — | — | 1 | 7.04 |
| CHEMBL363130 | — | — | 1 | 6.60 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.35 |
| CHEMBL364927 | — | — | 1 | 6.01 |
| CHEMBL190643 | — | — | 1 | 5.58 |
| CHEMBL370698 | — | — | 1 | 4.32 |
| CHEMBL363607 | — | — | 1 | - |
| CHEMBL190171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261720 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL363130 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL364927 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL190643 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL370698 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL363607 | — | IC50 | = | 790000.0 | nM | - |
| CHEMBL190171 | — | IC50 | > | 10000.0 | nM | - |