Assay Detail
Functional
CHEMBL833230
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In vitro inhibitory concentration against cell proliferation in human HCT116 (colon carcinoma) tumor cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.19 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261720 | — | — | 1 | 7.70 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.60 |
| CHEMBL187395 | — | — | 1 | 6.57 |
| CHEMBL364927 | — | — | 1 | 6.04 |
| CHEMBL190643 | — | — | 1 | 5.72 |
| CHEMBL190171 | — | — | 1 | 5.39 |
| CHEMBL370698 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261720 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL187395 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL364927 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL190643 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL190171 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL370698 | — | IC50 | = | 4700.0 | nM | 5.33 |