Assay Detail
Functional
CHEMBL833265
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound (after 5 min of addition) that induce LPA expressed in human platelets
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.94 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364797 | — | — | 1 | 8.00 |
| CHEMBL187459 | — | — | 1 | 7.80 |
| CHEMBL189959 | OLEOYL | — | 1 | 7.05 |
| CHEMBL187711 | PHOSPHORIC ACID MONODODECYL ESTER | — | 1 | 6.60 |
| CHEMBL187633 | PHOSPHORIC ACID MONOTETRADECYL ESTER | — | 1 | 6.37 |
| CHEMBL190349 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364797 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187459 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL189959 | OLEOYL | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL187711 | PHOSPHORIC ACID MONODODECYL ESTER | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL187633 | PHOSPHORIC ACID MONOTETRADECYL ESTER | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL190349 | — | EC50 | = | 1500.0 | nM | 5.82 |