Assay Detail
Functional
CHEMBL833298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against wild type Human immuno deficiency virus (EP13) was determined in an MT-4 cell line
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.51 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364455 | — | — | 1 | 8.59 |
| CHEMBL186009 | — | — | 1 | 8.59 |
| CHEMBL189610 | — | — | 1 | 8.54 |
| CHEMBL189179 | — | — | 1 | 8.23 |
| CHEMBL365652 | — | — | 1 | 8.04 |
| CHEMBL365435 | — | — | 1 | 8.04 |
| CHEMBL188793 | — | — | 1 | 7.96 |
| CHEMBL361093 | — | — | 1 | 7.89 |
| CHEMBL186058 | — | — | 1 | 7.85 |
| CHEMBL189254 | — | — | 1 | 7.75 |
| CHEMBL433973 | — | — | 1 | 7.72 |
| CHEMBL365653 | — | — | 1 | 7.70 |
| CHEMBL365038 | — | — | 1 | 7.66 |
| CHEMBL365909 | — | — | 1 | 7.58 |
| CHEMBL186111 | — | — | 1 | 7.30 |
| CHEMBL365455 | — | — | 1 | 7.28 |
| CHEMBL361726 | — | — | 1 | 7.25 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 7.03 |
| CHEMBL365668 | — | — | 1 | 6.88 |
| CHEMBL189006 | — | — | 1 | 6.82 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 6.48 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 6.40 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.36 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364455 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL186009 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL189610 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL189179 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL365652 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL365435 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL188793 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL361093 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL186058 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL189254 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL433973 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL365653 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL365038 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL365909 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL186111 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL365455 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL361726 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1163 | ATAZANAVIR | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL365668 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL189006 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL729 | LOPINAVIR | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 450.0 | nM | 6.35 |