Assay Detail
Functional
CHEMBL833354
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inhibitory concentration against Pneumocystis carinii
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Pneumocystis carinii |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.22 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185063 | — | — | 1 | 9.52 |
| CHEMBL185175 | — | — | 1 | 8.70 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.30 |
| CHEMBL9391 | — | — | 1 | 5.92 |
| CHEMBL365916 | — | — | 1 | 5.89 |
| CHEMBL185172 | — | — | 1 | 5.89 |
| CHEMBL181480 | — | — | 1 | 5.85 |
| CHEMBL185471 | — | — | 1 | 5.58 |
| CHEMBL2311116 | — | — | 1 | 5.28 |
| CHEMBL183814 | BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE | — | 1 | 4.87 |
| CHEMBL142952 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185063 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL185175 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL9391 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL365916 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL185172 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL181480 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL185471 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2311116 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL183814 | BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL142952 | — | IC50 | = | 22800.0 | nM | 4.64 |