Assay Detail
Functional
CHEMBL833366
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Inhibitory concentration against S1 cells was evaluated
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.45 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 8.43 |
| CHEMBL188372 | — | — | 1 | 8.14 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.04 |
| CHEMBL186875 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL188372 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL186875 | — | IC50 | = | 657.0 | nM | 6.18 |