Assay Detail
Functional
CHEMBL833369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity in an in vitro HIV replication assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.04 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93139 | — | — | 1 | 8.52 |
| CHEMBL179209 | — | — | 2 | 7.48 |
| CHEMBL179141 | — | — | 1 | 7.00 |
| CHEMBL178189 | — | — | 1 | 6.96 |
| CHEMBL426048 | — | — | 1 | 6.96 |
| CHEMBL360667 | — | — | 1 | 6.96 |
| CHEMBL361585 | — | — | 1 | 6.48 |
| CHEMBL180274 | — | — | 1 | 6.48 |
| CHEMBL180013 | — | — | 1 | - |
| CHEMBL182188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93139 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL179209 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL179141 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL178189 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL426048 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL360667 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL179209 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL361585 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL180274 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL180013 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL182188 | — | IC50 | > | 300.0 | nM | - |