Assay Detail
Functional
CHEMBL833393
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Antiproliferation activity against human colon cancer cell line (HCT116)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.11 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363160 | PHA-680632 | — | 1 | 7.35 |
| CHEMBL190252 | — | — | 1 | 6.66 |
| CHEMBL363857 | — | — | 1 | 6.24 |
| CHEMBL427170 | — | — | 1 | 6.05 |
| CHEMBL192928 | — | — | 1 | 5.70 |
| CHEMBL191816 | — | — | 1 | 5.68 |
| CHEMBL191402 | — | — | 1 | 5.66 |
| CHEMBL192575 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363160 | PHA-680632 | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL190252 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL363857 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL427170 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL192928 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL191816 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL191402 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL192575 | — | IC50 | = | 3000.0 | nM | 5.52 |