Assay Detail
Functional
CHEMBL833399
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Concentration required to inhibit proliferation of A375 human amelanotic melanoma cell growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.40 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371169 | — | — | 1 | 5.55 |
| CHEMBL188502 | — | — | 1 | 5.53 |
| CHEMBL190984 | — | — | 1 | 5.43 |
| CHEMBL372657 | — | — | 1 | 5.29 |
| CHEMBL188386 | — | — | 1 | 5.22 |
| CHEMBL177688 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371169 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL188502 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL190984 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL372657 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL188386 | — | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL177688 | — | IC50 | > | 10000.0 | nM | - |