Assay Detail
Functional
CHEMBL833401
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Concentration required for growth inhibition of human HCT116 colon tumor cell line (CCRF-CEM) was determined
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.30 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.59 |
| CHEMBL182739 | — | — | 1 | 8.26 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL182739 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.7 | nM | 8.06 |