Assay Detail
Functional
CHEMBL833448
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In vitro inhibitory concentration is measured by the incorporation of [14C]thymidine in human colon carcinoma HCT116 cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.38 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190460 | — | — | 1 | 6.98 |
| CHEMBL189937 | — | — | 1 | 6.66 |
| CHEMBL370237 | — | — | 1 | 6.48 |
| CHEMBL426818 | — | — | 1 | 6.47 |
| CHEMBL192945 | — | — | 1 | 6.12 |
| CHEMBL190096 | — | — | 1 | 6.08 |
| CHEMBL190200 | — | — | 1 | 5.87 |
| CHEMBL192641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190460 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL189937 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL370237 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL426818 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL192945 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL190096 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL190200 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL192641 | — | IC50 | > | 3000.0 | nM | - |