Assay Detail
Functional
CHEMBL833467
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]thymidine uptake in L1210 cells
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha1-acid glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.95 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155584 | — | — | 1 | 6.66 |
| CHEMBL348601 | — | — | 1 | 6.60 |
| CHEMBL182855 | — | — | 1 | 6.58 |
| CHEMBL154107 | — | — | 1 | 6.57 |
| CHEMBL932 | DIPYRIDAMOLE | 4.0 | 1 | 6.47 |
| CHEMBL347220 | — | — | 1 | 6.40 |
| CHEMBL154881 | — | — | 1 | 6.37 |
| CHEMBL154963 | — | — | 1 | 6.34 |
| CHEMBL369771 | — | — | 1 | 6.30 |
| CHEMBL154849 | — | — | 1 | 6.22 |
| CHEMBL156245 | — | — | 1 | 6.17 |
| CHEMBL157509 | — | — | 1 | 6.16 |
| CHEMBL182869 | — | — | 1 | 6.16 |
| CHEMBL180716 | — | — | 1 | 6.14 |
| CHEMBL183415 | — | — | 1 | 6.12 |
| CHEMBL185635 | — | — | 1 | 6.12 |
| CHEMBL362321 | — | — | 1 | 6.10 |
| CHEMBL350244 | — | — | 1 | 6.08 |
| CHEMBL179991 | — | — | 1 | 6.05 |
| CHEMBL182170 | — | — | 1 | 6.03 |
| CHEMBL185408 | — | — | 1 | 5.96 |
| CHEMBL2096699 | — | — | 1 | 5.96 |
| CHEMBL188670 | — | — | 1 | 5.85 |
| CHEMBL360462 | — | — | 1 | 5.73 |
| CHEMBL183236 | — | — | 1 | 5.68 |
| CHEMBL185864 | — | — | 1 | 5.62 |
| CHEMBL364550 | — | — | 1 | 5.58 |
| CHEMBL181762 | — | — | 1 | 5.52 |
| CHEMBL183712 | — | — | 1 | 5.43 |
| CHEMBL366314 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155584 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL348601 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL182855 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL154107 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL347220 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL154881 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL154963 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL369771 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL154849 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL156245 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL157509 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL182869 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL180716 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL185635 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL183415 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL362321 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL350244 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL179991 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL182170 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL185408 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2096699 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL188670 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL360462 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL183236 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL185864 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL364550 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL181762 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL183712 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL366314 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL368026 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL182365 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL362300 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL182420 | — | IC50 | = | 52000.0 | nM | 4.28 |