Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL833470

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration of fatty acid amide hydrolase using FP-Rh radioligand
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Fatty-acid amide hydrolase 1 (CHEMBL2243)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.
Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL.
Bioorg Med Chem Lett (2005) 15 : 1423 -1428
PubMed 15713400 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 7.04 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182199 1 10.00
CHEMBL179760 1 9.52
CHEMBL367966 1 9.52
CHEMBL182206 1 9.22
CHEMBL361529 1 9.10
CHEMBL178398 1 9.00
CHEMBL175854 1 9.00
CHEMBL424976 1 8.40
CHEMBL178563 1 8.40
CHEMBL177708 1 8.10
CHEMBL177577 1 8.00
CHEMBL361170 1 7.70
CHEMBL180625 1 7.70
CHEMBL177216 1 7.52
CHEMBL35925 1 7.40
CHEMBL366959 1 7.00
CHEMBL426230 1 6.70
CHEMBL362705 1 6.70
CHEMBL39412 1 5.70
CHEMBL91417 1 5.70
CHEMBL413727 1 5.30
CHEMBL426410 1 5.30
CHEMBL329187 1 5.30
CHEMBL91416 1 5.30
CHEMBL89946 1 5.19
CHEMBL366907 1 5.00
CHEMBL285678 1 5.00
CHEMBL90258 1 5.00
CHEMBL90308 1 5.00
CHEMBL93675 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182199 IC50 = 0.1 nM 10.00
CHEMBL179760 IC50 = 0.3 nM 9.52
CHEMBL367966 IC50 = 0.3 nM 9.52
CHEMBL182206 IC50 = 0.6 nM 9.22
CHEMBL361529 IC50 = 0.8 nM 9.10
CHEMBL178398 IC50 = 1.0 nM 9.00
CHEMBL175854 IC50 = 1.0 nM 9.00
CHEMBL424976 IC50 = 4.0 nM 8.40
CHEMBL178563 IC50 = 4.0 nM 8.40
CHEMBL177708 IC50 = 8.0 nM 8.10
CHEMBL177577 IC50 = 10.0 nM 8.00
CHEMBL361170 IC50 = 20.0 nM 7.70
CHEMBL180625 IC50 = 20.0 nM 7.70
CHEMBL177216 IC50 = 30.0 nM 7.52
CHEMBL35925 IC50 = 40.0 nM 7.40
CHEMBL366959 IC50 = 100.0 nM 7.00
CHEMBL426230 IC50 = 200.0 nM 6.70
CHEMBL362705 IC50 = 200.0 nM 6.70
CHEMBL39412 IC50 = 2000.0 nM 5.70
CHEMBL91417 IC50 = 2000.0 nM 5.70
CHEMBL413727 IC50 = 5000.0 nM 5.30
CHEMBL426410 IC50 = 5000.0 nM 5.30
CHEMBL329187 IC50 = 5000.0 nM 5.30
CHEMBL91416 IC50 = 5000.0 nM 5.30
CHEMBL89946 IC50 = 6400.0 nM 5.19
CHEMBL366907 IC50 = 10000.0 nM 5.00
CHEMBL285678 IC50 = 10000.0 nM 5.00
CHEMBL90258 IC50 = 10000.0 nM 5.00
CHEMBL90308 IC50 = 10000.0 nM 5.00
CHEMBL93675 IC50 = 30000.0 nM 4.52
CHEMBL181187 IC50 - nM -