Assay Detail
Binding
CHEMBL833493
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Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptor
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.14 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135974 | — | — | 1 | 9.08 |
| CHEMBL13647 | BMY-7378 | — | 1 | 9.03 |
| CHEMBL25554 | — | — | 1 | 8.68 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.46 |
| CHEMBL132378 | — | — | 1 | 8.43 |
| CHEMBL135973 | — | — | 1 | 8.26 |
| CHEMBL134428 | — | — | 1 | 7.65 |
| CHEMBL2112711 | — | — | 2 | 7.61 |
| CHEMBL2112713 | — | — | 2 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135974 | — | Ki | = | 0.8318 | nM | 9.08 |
| CHEMBL13647 | BMY-7378 | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL25554 | — | Ki | = | 2.089 | nM | 8.68 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 3.467 | nM | 8.46 |
| CHEMBL132378 | — | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL135973 | — | Ki | = | 5.495 | nM | 8.26 |
| CHEMBL134428 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL2112711 | — | Ki | = | 24.55 | nM | 7.61 |
| CHEMBL2112711 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL2112713 | — | Ki | = | 33.88 | nM | 7.47 |
| CHEMBL2112713 | — | Ki | = | 50.12 | nM | 7.30 |