Assay Detail
Binding
CHEMBL833500
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Inhibitory concentration against tubulin assembly
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.27 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277239 | — | — | 1 | 5.82 |
| CHEMBL142588 | COLCHICEINE | — | 1 | 5.54 |
| CHEMBL180388 | — | — | 1 | 5.42 |
| CHEMBL1080 | 2-DESMETHYLCOLCHICIN | — | 1 | 5.32 |
| CHEMBL180503 | — | — | 1 | 5.06 |
| CHEMBL183373 | — | — | 1 | 4.89 |
| CHEMBL183569 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277239 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL142588 | COLCHICEINE | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL180388 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1080 | 2-DESMETHYLCOLCHICIN | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL180503 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL183373 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL183569 | — | IC50 | = | 15000.0 | nM | 4.82 |