Assay Detail
Binding
CHEMBL833504
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Inhibition of bovine Geranylgeranyltransferase
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.88 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187254 | — | — | 1 | 7.06 |
| CHEMBL184044 | — | — | 1 | 6.66 |
| CHEMBL187128 | — | — | 1 | 6.62 |
| CHEMBL184916 | — | — | 1 | 6.38 |
| CHEMBL186617 | — | — | 1 | 6.25 |
| CHEMBL187807 | — | — | 1 | 6.14 |
| CHEMBL188127 | — | — | 1 | 6.09 |
| CHEMBL184330 | — | — | 1 | 6.06 |
| CHEMBL181748 | — | — | 1 | 6.00 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.96 |
| CHEMBL362881 | — | — | 1 | 5.89 |
| CHEMBL186641 | — | — | 1 | 5.89 |
| CHEMBL363524 | — | — | 1 | 5.85 |
| CHEMBL182816 | — | — | 1 | 5.75 |
| CHEMBL181442 | — | — | 1 | 5.68 |
| CHEMBL362338 | — | — | 1 | 5.66 |
| CHEMBL362519 | — | — | 1 | 5.64 |
| CHEMBL184568 | — | — | 1 | 5.64 |
| CHEMBL184537 | — | — | 1 | 5.47 |
| CHEMBL187037 | — | — | 1 | 5.26 |
| CHEMBL186906 | — | — | 1 | 5.17 |
| CHEMBL186927 | — | — | 1 | 5.09 |
| CHEMBL182810 | — | — | 1 | 5.07 |
| CHEMBL365289 | — | — | 1 | - |
| CHEMBL185416 | — | — | 1 | - |
| CHEMBL184425 | — | — | 1 | - |
| CHEMBL183953 | — | — | 1 | - |
| CHEMBL186715 | — | — | 1 | - |
| CHEMBL185053 | — | — | 1 | - |
| CHEMBL185058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187254 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL184044 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL187128 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL184916 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL186617 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL187807 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL188127 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL184330 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL181748 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL362881 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL186641 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL363524 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL182816 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL181442 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL362338 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL184568 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL362519 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL184537 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL187037 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL186906 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL186927 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL182810 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL182171 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL183313 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL365427 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL362750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185058 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185053 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL186715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL183953 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL184425 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL185416 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL365289 | — | IC50 | > | 10000.0 | nM | - |