Assay Detail
Binding
CHEMBL833528
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In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.62 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.05 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.92 |
| CHEMBL191941 | — | — | 1 | 7.40 |
| CHEMBL192789 | — | — | 1 | 7.22 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.10 |
| CHEMBL194818 | — | — | 1 | 6.96 |
| CHEMBL364960 | — | — | 1 | 6.37 |
| CHEMBL363398 | — | — | 1 | 6.32 |
| CHEMBL192678 | — | — | 1 | 6.00 |
| CHEMBL191352 | — | — | 1 | 5.72 |
| CHEMBL195391 | — | — | 1 | 5.37 |
| CHEMBL364238 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL191941 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL192789 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL118 | CELECOXIB | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL194818 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL364960 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL363398 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL192678 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL191352 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL195391 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL364238 | — | IC50 | = | 9900.0 | nM | 5.00 |