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Assay Detail

CHEMBL833546

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against human recombinant butyrylcholinesterase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Cholinesterase (CHEMBL1914)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Rational approach to discover multipotent anti-Alzheimer drugs.
Rosini M, Andrisano V, Bartolini M, Bolognesi ML, Hrelia P, Minarini A, Tarozzi A, Melchiorre C.
J Med Chem (2005) 48 : 360 -363
PubMed 15658850 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.63 8.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL425739 1 8.83
CHEMBL278963 1 8.49
CHEMBL424833 1 8.30
CHEMBL195067 1 8.07
CHEMBL194823 LIPOCRINE 1 7.97
CHEMBL195179 1 7.92
CHEMBL95 TACRINE 4.0 1 7.34
CHEMBL192682 1 7.32
CHEMBL363391 1 6.48
CHEMBL191758 1 5.59
CHEMBL134342 THIOCTIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL425739 IC50 = 1.48 nM 8.83
CHEMBL278963 IC50 = 3.24 nM 8.49
CHEMBL424833 IC50 = 5.04 nM 8.30
CHEMBL195067 IC50 = 8.58 nM 8.07
CHEMBL194823 LIPOCRINE IC50 = 10.8 nM 7.97
CHEMBL195179 IC50 = 12.0 nM 7.92
CHEMBL95 TACRINE IC50 = 45.8 nM 7.34
CHEMBL192682 IC50 = 47.5 nM 7.32
CHEMBL363391 IC50 = 329.0 nM 6.48
CHEMBL191758 IC50 = 2580.0 nM 5.59
CHEMBL134342 THIOCTIC ACID IC50 > 1000000.0 nM -