Assay Detail
Binding
CHEMBL833553
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Inhibition of cyclin dependent kinase 2-cyclin A
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.91 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190446 | — | — | 1 | 8.70 |
| CHEMBL192602 | — | — | 1 | 8.70 |
| CHEMBL193210 | — | — | 1 | 7.96 |
| CHEMBL192716 | — | — | 1 | 7.92 |
| CHEMBL370724 | — | — | 1 | 7.89 |
| CHEMBL366032 | — | — | 1 | 7.89 |
| CHEMBL192042 | — | — | 1 | 7.77 |
| CHEMBL193288 | — | — | 1 | 7.77 |
| CHEMBL191834 | — | — | 1 | 7.70 |
| CHEMBL192556 | — | — | 1 | 7.70 |
| CHEMBL192339 | — | — | 1 | 7.60 |
| CHEMBL359556 | — | — | 1 | 7.54 |
| CHEMBL115220 | — | — | 1 | 7.43 |
| CHEMBL191144 | — | — | 1 | 7.43 |
| CHEMBL370817 | — | — | 1 | 7.14 |
| CHEMBL373346 | — | — | 1 | 7.11 |
| CHEMBL365341 | — | — | 1 | 7.10 |
| CHEMBL366230 | — | — | 1 | 7.08 |
| CHEMBL191733 | — | — | 1 | 7.00 |
| CHEMBL372467 | — | — | 1 | 6.91 |
| CHEMBL193673 | — | — | 1 | 6.82 |
| CHEMBL192126 | — | — | 1 | 6.77 |
| CHEMBL195683 | — | — | 1 | 6.77 |
| CHEMBL193622 | — | — | 1 | 6.77 |
| CHEMBL192440 | — | — | 1 | 6.70 |
| CHEMBL190206 | — | — | 1 | 6.70 |
| CHEMBL191865 | — | — | 1 | 6.62 |
| CHEMBL189047 | — | — | 1 | 6.34 |
| CHEMBL193287 | — | — | 1 | 6.02 |
| CHEMBL191948 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190446 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL192602 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL193210 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL192716 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL370724 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL366032 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL192042 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL193288 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL191834 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL192556 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL192339 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL359556 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL115220 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL191144 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL370817 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL373346 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL365341 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL366230 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL191733 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL372467 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL193673 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL192126 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL195683 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL193622 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL192440 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL190206 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL191865 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL189047 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL193287 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL191948 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL190154 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL192471 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL192179 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL190178 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL189791 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL365988 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL365355 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL370036 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL192665 | — | IC50 | > | 10000.0 | nM | - |