Assay Detail
Binding
CHEMBL833562
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Inhibitory activity against neuronal nitric oxide synthase in human
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.89 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364188 | — | — | 1 | 7.27 |
| CHEMBL183892 | — | — | 1 | 7.24 |
| CHEMBL185444 | — | — | 1 | 7.12 |
| CHEMBL363318 | — | — | 1 | 7.12 |
| CHEMBL185247 | — | — | 1 | 6.95 |
| CHEMBL40391 | — | — | 1 | 6.85 |
| CHEMBL184794 | — | — | 1 | 6.70 |
| CHEMBL184355 | — | — | 1 | 6.63 |
| CHEMBL360626 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364188 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL183892 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL185444 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL363318 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL185247 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL40391 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL184794 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL184355 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL360626 | — | IC50 | = | 810.0 | nM | 6.09 |