Assay Detail
Functional
CHEMBL833575
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to inhibit Epstein-barr virus replication in H-1 cells in DNA hybridization assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human gammaherpesvirus 4 |
| Cell Type | H-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.42 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364236 | — | — | 1 | 5.64 |
| CHEMBL427352 | — | — | 1 | 5.52 |
| CHEMBL195174 | — | — | 1 | 5.47 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.30 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 5.16 |
| CHEMBL157102 | — | — | 1 | - |
| CHEMBL192395 | — | — | 1 | - |
| CHEMBL362940 | — | — | 1 | - |
| CHEMBL372938 | — | — | 1 | - |
| CHEMBL192301 | — | — | 1 | - |
| CHEMBL195171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364236 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL427352 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL195174 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL265948 | FILOCICLOVIR | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL157102 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL192395 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL362940 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL372938 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL192301 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL195171 | — | EC50 | > | 20000.0 | nM | - |