Assay Detail
Functional
CHEMBL833627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity by [Ca2+] uptake in CHO cells expressing rat TRPV1 at 10-30 uM; NE = Not effective
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL5102) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.56 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424803 | — | — | 1 | 5.72 |
| CHEMBL189507 | — | — | 1 | 5.39 |
| CHEMBL391997 | CAPSAZEPINE | — | 1 | - |
| CHEMBL228451 | — | — | 1 | - |
| CHEMBL388824 | — | — | 1 | - |
| CHEMBL189418 | — | — | 1 | - |
| CHEMBL189177 | — | — | 1 | - |
| CHEMBL191024 | — | — | 1 | - |
| CHEMBL363267 | — | — | 1 | - |
| CHEMBL190637 | — | — | 1 | - |
| CHEMBL365213 | — | — | 1 | - |
| CHEMBL370055 | — | — | 1 | - |
| CHEMBL425180 | — | — | 1 | - |
| CHEMBL187838 | — | — | 1 | - |
| CHEMBL370264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424803 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL189507 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL391997 | CAPSAZEPINE | EC50 | - | nM | - | |
| CHEMBL228451 | — | EC50 | - | nM | - | |
| CHEMBL388824 | — | EC50 | - | nM | - | |
| CHEMBL189418 | — | EC50 | - | nM | - | |
| CHEMBL189177 | — | EC50 | - | nM | - | |
| CHEMBL191024 | — | EC50 | - | nM | - | |
| CHEMBL363267 | — | EC50 | - | nM | - | |
| CHEMBL190637 | — | EC50 | - | nM | - | |
| CHEMBL365213 | — | EC50 | - | nM | - | |
| CHEMBL370055 | — | EC50 | - | nM | - | |
| CHEMBL425180 | — | EC50 | - | nM | - | |
| CHEMBL187838 | — | EC50 | - | nM | - | |
| CHEMBL370264 | — | EC50 | - | nM | - |