Assay Detail
Functional
CHEMBL833648
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Inhibition of glucocorticoid receptor dependent alkaline phosphatase activity
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.19 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406064 | — | — | 1 | 9.42 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.36 |
| CHEMBL266673 | — | — | 1 | 9.12 |
| CHEMBL427568 | — | — | 2 | 8.96 |
| CHEMBL2096708 | — | — | 1 | 8.96 |
| CHEMBL415621 | — | — | 1 | 8.96 |
| CHEMBL408376 | — | — | 1 | 8.92 |
| CHEMBL364368 | — | — | 1 | 8.85 |
| CHEMBL266935 | — | — | 1 | 8.85 |
| CHEMBL265125 | — | — | 1 | 8.57 |
| CHEMBL409123 | — | — | 1 | 8.37 |
| CHEMBL414318 | — | — | 1 | 8.07 |
| CHEMBL2096804 | — | — | 1 | 7.92 |
| CHEMBL406027 | — | — | 1 | 7.82 |
| CHEMBL384975 | — | — | 1 | 7.82 |
| CHEMBL407672 | — | — | 1 | 7.43 |
| CHEMBL414041 | — | — | 1 | 7.43 |
| CHEMBL263942 | — | — | 1 | 7.31 |
| CHEMBL411185 | — | — | 1 | 7.30 |
| CHEMBL440251 | — | — | 1 | 7.28 |
| CHEMBL266656 | — | — | 1 | 7.00 |
| CHEMBL436859 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406064 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL266673 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL427568 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2096708 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL415621 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL408376 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL364368 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL266935 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL265125 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL409123 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL414318 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL427568 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2096804 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL384975 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL406027 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL407672 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL414041 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL263942 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL411185 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL440251 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL266656 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL436859 | — | Ki | = | 250.0 | nM | 6.60 |