Assay Detail
Functional
CHEMBL833776
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Concentration required for 50% growth inhibition of human A549 cancer cell lines after 3 days of culture
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.97 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176316 | — | — | 1 | 8.70 |
| CHEMBL175946 | — | — | 1 | 8.52 |
| CHEMBL433564 | — | — | 1 | 8.40 |
| CHEMBL175947 | — | — | 1 | 8.40 |
| CHEMBL175452 | — | — | 1 | 8.40 |
| CHEMBL360322 | — | — | 1 | 8.30 |
| CHEMBL178993 | — | — | 1 | 8.10 |
| CHEMBL369587 | — | — | 1 | 8.05 |
| CHEMBL177836 | — | — | 1 | 7.75 |
| CHEMBL175806 | — | — | 1 | 7.60 |
| CHEMBL180496 | — | — | 1 | 7.38 |
| CHEMBL175716 | — | — | 1 | 7.32 |
| CHEMBL368047 | — | — | 1 | 7.13 |
| CHEMBL369515 | — | — | 1 | 6.90 |
| CHEMBL175719 | — | — | 1 | 6.38 |
| CHEMBL175769 | — | — | 1 | 6.33 |
| CHEMBL175921 | — | — | 1 | 6.20 |
| CHEMBL434923 | — | — | 1 | 6.18 |
| CHEMBL360496 | — | — | 1 | 5.73 |
| CHEMBL366906 | — | — | 1 | 5.59 |
| CHEMBL178933 | — | — | 1 | 5.57 |
| CHEMBL366970 | — | — | 1 | 5.44 |
| CHEMBL175981 | — | — | 1 | 5.43 |
| CHEMBL367124 | — | — | 1 | 5.33 |
| CHEMBL427124 | — | — | 1 | 5.12 |
| CHEMBL426228 | — | — | 1 | - |
| CHEMBL262795 | — | — | 1 | - |
| CHEMBL360685 | — | — | 1 | - |
| CHEMBL367694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176316 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL175946 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL433564 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL175947 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL175452 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL360322 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL178993 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL369587 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL177836 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL175806 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL180496 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL175716 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL368047 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL369515 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL175719 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL175769 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL175921 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL434923 | — | IC50 | = | 657.0 | nM | 6.18 |
| CHEMBL360496 | — | IC50 | = | 1861.0 | nM | 5.73 |
| CHEMBL366906 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL178933 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL366970 | — | IC50 | = | 3652.0 | nM | 5.44 |
| CHEMBL175981 | — | IC50 | = | 3705.0 | nM | 5.43 |
| CHEMBL367124 | — | IC50 | = | 4731.0 | nM | 5.33 |
| CHEMBL427124 | — | IC50 | = | 7544.0 | nM | 5.12 |
| CHEMBL426228 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL262795 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360685 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL367694 | — | IC50 | > | 10000.0 | nM | - |