Assay Detail
Functional
CHEMBL833804
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Inhibitory concentration value against human MEL-28 or human cancer HeLa tumor cell line
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.35 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180217 | — | — | 1 | 8.52 |
| CHEMBL84903 | — | — | 1 | 8.52 |
| CHEMBL85065 | NAPHTHYLCOMBRETASTATIN | — | 1 | 7.70 |
| CHEMBL451490 | — | — | 1 | 7.62 |
| CHEMBL442784 | — | — | 1 | 7.47 |
| CHEMBL175431 | — | — | 1 | 7.40 |
| CHEMBL180024 | — | — | 1 | 6.96 |
| CHEMBL175504 | — | — | 1 | 6.60 |
| CHEMBL176291 | — | — | 1 | 6.60 |
| CHEMBL78126 | — | — | 1 | 6.51 |
| CHEMBL3706761 | — | — | 1 | 6.48 |
| CHEMBL82612 | — | — | 1 | 6.41 |
| CHEMBL175660 | — | — | 1 | 6.34 |
| CHEMBL369169 | — | — | 1 | 5.82 |
| CHEMBL361539 | — | — | 1 | 5.79 |
| CHEMBL180218 | — | — | 1 | 5.54 |
| CHEMBL179670 | — | — | 1 | 5.51 |
| CHEMBL3706760 | — | — | 1 | 5.51 |
| CHEMBL176231 | — | — | 1 | 5.51 |
| CHEMBL368498 | — | — | 1 | 5.50 |
| CHEMBL366738 | — | — | 1 | 5.49 |
| CHEMBL175445 | — | — | 1 | 5.49 |
| CHEMBL426770 | — | — | 1 | 5.45 |
| CHEMBL367610 | — | — | 1 | 5.44 |
| CHEMBL1795038 | — | — | 1 | 5.44 |
| CHEMBL175897 | — | — | 1 | 5.44 |
| CHEMBL368232 | — | — | 1 | - |
| CHEMBL177278 | — | — | 1 | - |
| CHEMBL176059 | — | — | 1 | - |
| CHEMBL175920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180217 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL84903 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL85065 | NAPHTHYLCOMBRETASTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL451490 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL442784 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL175431 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL180024 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL175504 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL176291 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL78126 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3706761 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL82612 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL175660 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL369169 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL361539 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL180218 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL179670 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL3706760 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL176231 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL368498 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL175445 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL366738 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL426770 | — | IC50 | = | 3590.0 | nM | 5.45 |
| CHEMBL367610 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL1795038 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL175897 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL176943 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL176232 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL366613 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL176130 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL369756 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL175834 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL175891 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL175429 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL179194 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL175920 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL176059 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL177278 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL368232 | — | IC50 | > | 5000.0 | nM | - |