Assay Detail
Functional
CHEMBL833826
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Effective concentration of compound against intracellular calcium mobilization in rat
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.83 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | 7.34 |
| CHEMBL195344 | — | — | 1 | 7.11 |
| CHEMBL364058 | — | — | 1 | 6.90 |
| CHEMBL365533 | — | — | 1 | 6.85 |
| CHEMBL370678 | — | — | 1 | 6.65 |
| CHEMBL194545 | — | — | 1 | 6.65 |
| CHEMBL435108 | SALVINORIN A (ESTER) | — | 1 | 6.61 |
| CHEMBL370680 | — | — | 1 | 6.50 |
| CHEMBL425016 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL195344 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL364058 | — | EC50 | = | 126.0 | nM | 6.90 |
| CHEMBL365533 | — | EC50 | = | 141.0 | nM | 6.85 |
| CHEMBL370678 | — | EC50 | = | 223.0 | nM | 6.65 |
| CHEMBL194545 | — | EC50 | = | 223.0 | nM | 6.65 |
| CHEMBL435108 | SALVINORIN A (ESTER) | EC50 | = | 244.0 | nM | 6.61 |
| CHEMBL370680 | — | EC50 | = | 315.0 | nM | 6.50 |
| CHEMBL425016 | — | EC50 | > | 10000.0 | nM | - |