Assay Detail
Functional
CHEMBL833834
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Antagonist activity towards alpha-MSH stimulated accumulation of cAMP in HEK 293 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.55 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360716 | — | — | 1 | 8.33 |
| CHEMBL182277 | — | — | 1 | 7.51 |
| CHEMBL341982 | — | — | 1 | 7.40 |
| CHEMBL2113023 | — | — | 1 | 6.68 |
| CHEMBL182900 | — | — | 1 | 6.68 |
| CHEMBL181788 | — | — | 1 | 6.66 |
| CHEMBL362841 | — | — | 1 | 6.64 |
| CHEMBL368023 | — | — | 1 | 6.48 |
| CHEMBL183610 | — | — | 1 | 6.46 |
| CHEMBL2113020 | — | — | 1 | 6.44 |
| CHEMBL366706 | — | — | 1 | 6.44 |
| CHEMBL360296 | — | — | 1 | 6.44 |
| CHEMBL2113019 | — | — | 1 | 6.41 |
| CHEMBL369104 | — | — | 1 | 6.40 |
| CHEMBL362850 | — | — | 1 | 6.36 |
| CHEMBL366708 | — | — | 1 | 6.28 |
| CHEMBL368022 | — | — | 1 | 6.26 |
| CHEMBL180545 | — | — | 1 | 6.25 |
| CHEMBL180304 | — | — | 1 | 6.24 |
| CHEMBL369348 | — | — | 1 | 6.24 |
| CHEMBL183134 | — | — | 1 | 6.20 |
| CHEMBL181277 | — | — | 1 | 6.19 |
| CHEMBL2113022 | — | — | 1 | 6.14 |
| CHEMBL183114 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360716 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL182277 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL341982 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2113023 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL182900 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL181788 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL362841 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL368023 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL183610 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2113020 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL366706 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL360296 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2113019 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL369104 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL362850 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL366708 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL368022 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL180545 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL180304 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL369348 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL183134 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL181277 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2113022 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL183114 | — | EC50 | = | 750.0 | nM | 6.12 |