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Assay Detail

CHEMBL833980

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Functional
In vitro antiprotozoal activity for Plasmodium falciparum K1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
Arafa RK, Brun R, Wenzler T, Tanious FA, Wilson WD, Stephens CE, Boykin DW.
J Med Chem (2005) 48 : 5480 -5488
PubMed 16107146 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.43 8.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363001 1 8.64
CHEMBL192282 1 8.00
CHEMBL190969 1 7.88
CHEMBL24057 FURAMIDINE -1.0 1 7.81
CHEMBL55 PENTAMIDINE 4.0 1 7.46
CHEMBL363717 1 7.45
CHEMBL365264 1 6.64
CHEMBL189424 1 6.57
CHEMBL191371 1 6.46
CHEMBL370274 1 6.32
CHEMBL191313 1 5.92
CHEMBL192722 1 5.52
CHEMBL190681 1 5.50
CHEMBL192807 1 5.43
CHEMBL190005 1 5.39
CHEMBL189383 1 5.20
CHEMBL190394 1 4.99
CHEMBL365295 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363001 IC50 = 2.3 nM 8.64
CHEMBL192282 IC50 = 10.0 nM 8.00
CHEMBL190969 IC50 = 13.3 nM 7.88
CHEMBL24057 FURAMIDINE IC50 = 15.5 nM 7.81
CHEMBL55 PENTAMIDINE IC50 = 34.6 nM 7.46
CHEMBL363717 IC50 = 35.7 nM 7.45
CHEMBL365264 IC50 = 227.0 nM 6.64
CHEMBL189424 IC50 = 268.0 nM 6.57
CHEMBL191371 IC50 = 351.0 nM 6.46
CHEMBL370274 IC50 = 481.0 nM 6.32
CHEMBL191313 IC50 = 1200.0 nM 5.92
CHEMBL192722 IC50 = 3000.0 nM 5.52
CHEMBL190681 IC50 = 3200.0 nM 5.50
CHEMBL192807 IC50 = 3700.0 nM 5.43
CHEMBL190005 IC50 = 4100.0 nM 5.39
CHEMBL189383 IC50 = 6300.0 nM 5.20
CHEMBL190394 IC50 = 10300.0 nM 4.99
CHEMBL365295 IC50 = 30200.0 nM 4.52