Assay Detail
Functional
CHEMBL834063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibitory activity against MTX resistant subline of CCRF-CEM human lymphoblastic leukemia cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.70 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.21 |
| CHEMBL192632 | — | — | 1 | 6.07 |
| CHEMBL365307 | — | — | 1 | 5.52 |
| CHEMBL323565 | — | — | 1 | 5.37 |
| CHEMBL193275 | — | — | 1 | 5.31 |
| CHEMBL223279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL192632 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL365307 | — | EC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL323565 | — | EC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL193275 | — | EC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL223279 | — | EC50 | >= | 4600.0 | nM | - |