Assay Detail
Functional
CHEMBL834112
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Agonist activity against mu opioid receptor of guinea pig ileum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.77 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371856 | — | — | 1 | 9.29 |
| CHEMBL2181202 | — | — | 1 | 8.85 |
| CHEMBL370701 | — | — | 1 | 7.20 |
| CHEMBL3143756 | — | — | 1 | 5.72 |
| CHEMBL3143757 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371856 | — | IC50 | = | 0.509 | nM | 9.29 |
| CHEMBL2181202 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL370701 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3143756 | — | IC50 | = | 1887.0 | nM | 5.72 |
| CHEMBL3143757 | — | IC50 | > | 10000.0 | nM | - |