Assay Detail
Functional
CHEMBL834135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration of compound to inhibit human immunodeficiency virus HIV-1 strain N119 multiplication in MT-4 infected cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.75 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434333 | — | — | 1 | 6.52 |
| CHEMBL178164 | — | — | 1 | 6.40 |
| CHEMBL178880 | — | — | 1 | 6.30 |
| CHEMBL179744 | — | — | 1 | 6.00 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.75 |
| CHEMBL180477 | — | — | 1 | 5.62 |
| CHEMBL361382 | — | — | 1 | 5.57 |
| CHEMBL360887 | — | — | 1 | 5.48 |
| CHEMBL35033 | EMIVIRINE | 2.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434333 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL178164 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL178880 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL179744 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL991 | STAVUDINE | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL180477 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL361382 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL360887 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL35033 | EMIVIRINE | EC50 | = | 79000.0 | nM | 4.10 |