Assay Detail
Functional
CHEMBL834239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency against cAMP formation in CHO cells expressing recombinant human A2A receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.14 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368880 | — | — | 1 | 8.85 |
| CHEMBL361925 | — | — | 1 | 8.80 |
| CHEMBL2096798 | — | — | 1 | 8.52 |
| CHEMBL186403 | — | — | 1 | 8.51 |
| CHEMBL360837 | — | — | 1 | 8.10 |
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 8.06 |
| CHEMBL464859 | NECA | — | 1 | 7.30 |
| CHEMBL360646 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368880 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL361925 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2096798 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL186403 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL360837 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL186113 | GW-328267 | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL464859 | NECA | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL360646 | — | EC50 | = | 97.0 | nM | 7.01 |