Assay Detail
Functional
CHEMBL834252
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilating activity in rat aorta strip in absence of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.38 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363325 | — | — | 1 | 8.00 |
| CHEMBL189804 | — | — | 1 | 8.00 |
| CHEMBL360593 | — | — | 1 | 7.40 |
| CHEMBL187824 | — | — | 1 | 6.96 |
| CHEMBL188760 | — | — | 1 | 6.00 |
| CHEMBL188200 | — | — | 1 | 5.92 |
| CHEMBL187933 | — | — | 1 | 4.40 |
| CHEMBL188554 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363325 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL189804 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL360593 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL187824 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL188760 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL188200 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL187933 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL188554 | — | EC50 | = | 41000.0 | nM | 4.39 |