Assay Detail
Functional
CHEMBL834353
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% of HIV (human immunodeficiency virus) replication
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.51 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431573 | — | — | 1 | 8.23 |
| CHEMBL269559 | — | — | 1 | 7.40 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.40 |
| CHEMBL363096 | — | — | 1 | 6.66 |
| CHEMBL364600 | — | — | 1 | 5.55 |
| CHEMBL184462 | — | — | 1 | 5.19 |
| CHEMBL364099 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431573 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL269559 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL363096 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL364600 | — | EC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL184462 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL364099 | — | EC50 | = | 6900.0 | nM | 5.16 |