Assay Detail
Functional
CHEMBL834384
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Inhibitory concentration against rat vascular smooth muscle tissue
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Smooth muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.99 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.89 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.46 |
| CHEMBL181 | DIAZOXIDE | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49035 | CROMAKALIM | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL181 | DIAZOXIDE | IC50 | = | 23800.0 | nM | 4.62 |