Assay Detail
Functional
CHEMBL834405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required to inhibit hepatitis B virus replication in 2.2.15 cells in DNA hybridization assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.70 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.30 |
| CHEMBL372938 | — | — | 1 | 6.10 |
| CHEMBL195174 | — | — | 1 | 5.39 |
| CHEMBL427352 | — | — | 1 | 4.89 |
| CHEMBL364236 | — | — | 1 | 4.82 |
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | - |
| CHEMBL157102 | — | — | 1 | - |
| CHEMBL192395 | — | — | 1 | - |
| CHEMBL362940 | — | — | 1 | - |
| CHEMBL192301 | — | — | 1 | - |
| CHEMBL195171 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL372938 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL195174 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL427352 | — | EC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL364236 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL265948 | FILOCICLOVIR | EC50 | > | 10000.0 | nM | - |
| CHEMBL157102 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL192395 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL362940 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL192301 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL195171 | — | EC50 | > | 20000.0 | nM | - |