Assay Detail
Functional
CHEMBL834406
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Effective concentration required to inhibit vaccinia virus plaque formation in human foreskin fibroblast (HFF) cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.48 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372934 | — | — | 1 | 6.22 |
| CHEMBL190820 | — | — | 1 | 6.10 |
| CHEMBL370093 | — | — | 1 | 6.00 |
| CHEMBL1512080 | METHISAZONE | 2.0 | 1 | 5.48 |
| CHEMBL365164 | — | — | 1 | 5.17 |
| CHEMBL333137 | — | — | 1 | 4.85 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372934 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL190820 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL370093 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1512080 | METHISAZONE | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL365164 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL333137 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 27000.0 | nM | 4.57 |