Assay Detail
Functional
CHEMBL834471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mu opioid receptor mediated GTPgammaS binding to CHO cell membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.25 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | 4.0 | 1 | 7.24 |
| CHEMBL366311 | — | — | 1 | 6.82 |
| CHEMBL186527 | — | — | 1 | 5.89 |
| CHEMBL188558 | — | — | 1 | 5.67 |
| CHEMBL361274 | — | — | 1 | 5.62 |
| CHEMBL361033 | — | — | 1 | - |
| CHEMBL408680 | — | — | 1 | - |
| CHEMBL362514 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL841 | LOPERAMIDE | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL366311 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL186527 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL188558 | — | EC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL361274 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL361033 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL408680 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL362514 | — | EC50 | > | 10000.0 | nM | - |