Assay Detail
Functional
CHEMBL834474
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Concentration required to inhibit 50% of HIV-1 (human immunodeficiency virus-1) replication
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.38 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185772 | — | — | 1 | 10.70 |
| CHEMBL282915 | — | — | 1 | 9.18 |
| CHEMBL292426 | — | — | 1 | 9.06 |
| CHEMBL186312 | — | — | 1 | 8.89 |
| CHEMBL186953 | — | — | 1 | 8.77 |
| CHEMBL186231 | — | — | 1 | 8.36 |
| CHEMBL186230 | — | — | 1 | 8.25 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.21 |
| CHEMBL363997 | — | — | 1 | 7.70 |
| CHEMBL186769 | — | — | 1 | 7.22 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 5.85 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185772 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL282915 | — | EC50 | = | 0.66 | nM | 9.18 |
| CHEMBL292426 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL186312 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL186953 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL186231 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL186230 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL363997 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL186769 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL269277 | BETULINIC ACID | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL404519 | BEVIRIMAT | EC50 | < | 0.35 | nM | - |