Assay Detail
Functional
CHEMBL834626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against KM20 cells was evaluated
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM20 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.09 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 8.74 |
| CHEMBL181650 | — | — | 1 | 8.22 |
| CHEMBL188682 | — | — | 1 | 8.18 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.05 |
| CHEMBL362118 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL181650 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL188682 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL362118 | — | IC50 | = | 53.0 | nM | 7.28 |