Assay Detail
Functional
CHEMBL834635
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In vitro inhibitory activity against Staphylococcus aureus
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Staphylococcus aureus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.54 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186155 | — | — | 1 | 8.70 |
| CHEMBL364183 | — | — | 1 | 6.10 |
| CHEMBL187639 | — | — | 1 | 6.05 |
| CHEMBL361655 | — | — | 1 | 5.89 |
| CHEMBL363090 | — | — | 1 | 5.85 |
| CHEMBL360638 | — | — | 1 | 5.82 |
| CHEMBL186285 | — | — | 1 | 5.77 |
| CHEMBL185719 | — | — | 1 | 5.70 |
| CHEMBL186355 | — | — | 1 | 5.70 |
| CHEMBL186475 | — | — | 1 | 5.66 |
| CHEMBL184732 | — | — | 1 | 5.66 |
| CHEMBL364597 | — | — | 1 | 5.64 |
| CHEMBL183958 | — | — | 1 | 5.47 |
| CHEMBL187965 | — | — | 1 | 5.42 |
| CHEMBL361658 | — | — | 1 | 5.40 |
| CHEMBL186122 | — | — | 1 | 5.31 |
| CHEMBL364861 | — | — | 1 | 5.19 |
| CHEMBL364867 | — | — | 1 | 5.12 |
| CHEMBL186604 | — | — | 1 | 5.06 |
| CHEMBL365246 | — | — | 1 | 5.03 |
| CHEMBL184922 | — | — | 1 | 4.90 |
| CHEMBL186225 | — | — | 1 | 4.62 |
| CHEMBL187206 | — | — | 1 | 4.42 |
| CHEMBL185977 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186155 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL364183 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL187639 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL361655 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL363090 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL360638 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL186285 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL185719 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL186355 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL186475 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL184732 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL364597 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL183958 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL187965 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL361658 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL186122 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL364861 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL364867 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL186604 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL365246 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL184922 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL186225 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL187206 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL185977 | — | IC50 | = | 42000.0 | nM | 4.38 |