Assay Detail
Functional
CHEMBL834651
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Inhibition of MGBG-resistant CHO-MG cell proliferation, no polyamine transporter activity
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-MG |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of dihydromotuporamine derivatives in cells containing active polyamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.77 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536727 | — | — | 1 | 5.47 |
| CHEMBL371814 | — | — | 1 | 5.00 |
| CHEMBL534925 | — | — | 1 | 4.66 |
| CHEMBL366024 | — | — | 1 | 4.55 |
| CHEMBL541629 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536727 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL371814 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL534925 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL366024 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL541629 | — | IC50 | = | 66700.0 | nM | 4.18 |