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Assay Detail

CHEMBL834704

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Functional
In vitro inhibitory activity against human leukemia K562IU cell line
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Intermediate

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.
Franchetti P, Cappellacci L, Pasqualini M, Petrelli R, Vita P, Jayaram HN, Horvath Z, Szekeres T, Grifantini M.
J Med Chem (2005) 48 : 4983 -4989
PubMed 16033277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.39 4.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL285819 1 4.71
CHEMBL480143 1 4.42
CHEMBL610587 1 4.03
CHEMBL3143984 1 -
CHEMBL73809 1 -
CHEMBL606495 1 -
CHEMBL610319 1 -
CHEMBL610813 1 -
CHEMBL610318 1 -
CHEMBL611093 1 -
CHEMBL383144 1 -
CHEMBL2113423 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL285819 IC50 = 19500.0 nM 4.71
CHEMBL480143 IC50 = 38300.0 nM 4.42
CHEMBL610587 IC50 = 93800.0 nM 4.03
CHEMBL3143984 IC50 > 100000.0 nM -
CHEMBL73809 IC50 > 100000.0 nM -
CHEMBL606495 IC50 > 100000.0 nM -
CHEMBL610319 IC50 > 100000.0 nM -
CHEMBL610813 IC50 > 100000.0 nM -
CHEMBL610318 IC50 > 100000.0 nM -
CHEMBL611093 IC50 > 100000.0 nM -
CHEMBL383144 IC50 > 100000.0 nM -
CHEMBL2113423 IC50 > 100000.0 nM -