Assay Detail

CHEMBL834713

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Functional

Inhibitory concentration against human breast cancer MCF-7 cell lines

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

Open DB target context

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Intermediate

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity.

Cheng H, Cao X, Xian M, Fang L, Cai TB, Ji JJ, Tunac JB, Sun D, Wang PG.
J Med Chem (2005) 48 : 645 -652
PubMed 15658879 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.19	8.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL278315	GELDANAMYCIN	2.0	1	8.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL278315	GELDANAMYCIN	IC50	=	6.5	nM	8.19