Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL834729

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against Dictyostelium discoideum cell growth
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Fungi
Confidence 1 — Organism
Curated By Intermediate

Target

Dictyostelium discoideum (CHEMBL612373)
Type ORGANISM
Organism Dictyostelium discoideum

Publication

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Sanders JM, Song Y, Chan JM, Zhang Y, Jennings S, Kosztowski T, Odeh S, Flessner R, Schwerdtfeger C, Kotsikorou E, Meints GA, Gómez AO, González-Pacanowska D, Raker AM, Wang H, van Beek ER, Papapoulos SE, Morita CT, Oldfield E.
J Med Chem (2005) 48 : 2957 -2963
PubMed 15828834 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.22 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193356 1 5.82
CHEMBL191634 1 5.68
CHEMBL192017 1 5.64
CHEMBL4303669 ZOLEDRONIC ACID 4.0 1 5.54
CHEMBL193619 1 5.54
CHEMBL373332 1 5.54
CHEMBL923 RISEDRONIC ACID 4.0 1 5.52
CHEMBL192342 1 5.42
CHEMBL193722 1 5.34
CHEMBL192043 1 5.25
CHEMBL363145 1 5.22
CHEMBL192938 1 5.04
CHEMBL363434 1 4.96
CHEMBL190258 1 4.92
CHEMBL425896 1 4.70
CHEMBL870 ALENDRONIC ACID 4.0 1 4.50
CHEMBL193131 1 4.14
CHEMBL834 PAMIDRONIC ACID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193356 IC50 = 1500.0 nM 5.82
CHEMBL191634 IC50 = 2100.0 nM 5.68
CHEMBL192017 IC50 = 2300.0 nM 5.64
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 2900.0 nM 5.54
CHEMBL193619 IC50 = 2900.0 nM 5.54
CHEMBL373332 IC50 = 2900.0 nM 5.54
CHEMBL923 RISEDRONIC ACID IC50 = 3000.0 nM 5.52
CHEMBL192342 IC50 = 3800.0 nM 5.42
CHEMBL193722 IC50 = 4600.0 nM 5.34
CHEMBL192043 IC50 = 5600.0 nM 5.25
CHEMBL363145 IC50 = 6000.0 nM 5.22
CHEMBL192938 IC50 = 9200.0 nM 5.04
CHEMBL363434 IC50 = 11000.0 nM 4.96
CHEMBL190258 IC50 = 12000.0 nM 4.92
CHEMBL425896 IC50 = 20000.0 nM 4.70
CHEMBL870 ALENDRONIC ACID IC50 = 32000.0 nM 4.50
CHEMBL193131 IC50 = 72000.0 nM 4.14
CHEMBL834 PAMIDRONIC ACID IC50 = 167000.0 nM -