Assay Detail
Functional
CHEMBL834775
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against gel filtered platelet aggregation induced by alpha thrombin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.40 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257898 | — | — | 1 | 7.80 |
| CHEMBL363003 | — | — | 1 | 7.77 |
| CHEMBL175620 | — | — | 1 | 7.66 |
| CHEMBL361379 | — | — | 1 | 7.47 |
| CHEMBL401737 | — | — | 1 | 7.43 |
| CHEMBL176348 | — | — | 1 | 7.33 |
| CHEMBL175612 | — | — | 1 | 7.12 |
| CHEMBL273196 | EFEGATRAN | 2.0 | 1 | 7.08 |
| CHEMBL367973 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257898 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL363003 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL175620 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL361379 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL401737 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL176348 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL175612 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL273196 | EFEGATRAN | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL367973 | — | IC50 | = | 120.0 | nM | 6.92 |